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Hedonic motivation1/10/2024 Such a deficit may arise from impaired ability to represent the value of future rewards. This motivational impairment was ameliorated when the transgene was turned off and D2R levels were normalized. D2R-OE mice pressed less for the preferred milk and consumed more of the freely available less preferred chow, indicating that striatal overexpression of postsynaptic D2Rs can alter cost/benefit computations, leading to a motivational deficit. To further understand the basis of the motivational deficit, mice were given a choice between pressing a lever for access to a preferred reward (evaporated milk) or consuming a freely available less preferred reward (home-cage chow). We found no difference between D2R-OE mice and controls in hedonic reactions. We assessed licking behavior and video-scored positive hedonic facial reactions to increasing concentrations of sucrose in control and D2R-OE mice. First, we assessed whether hedonic reaction to reward is intact in D2R-OE mice. The present studies investigated the basis for this deficit. Specifically, D2R-OE mice display a deficit in incentive motivation. We previously showed that mice that selectively and reversibly overexpress striatal D2 receptors (D2R-OE) model the negative symptoms of schizophrenia.
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